Tim Blake Nelson most recently wrote, directed, produced and starred in Anesthesia, an ensemble drama examining life in present day New York City. The film also stars Kristen Stewart, Glenn Close, Sam Waterson, Michael K. Williams and Corey Stoll.

Previously, Nelson wrote, directed and produced Leaves of Grass, a dark comedy starring Edward Norton, Keri Russell, Susan Sarandon and Richard Dreyfuss. The film premiered at the 2009 Toronto Film Festival and was released in August 2010. Nelson also plays a supporting role in the film which was distributed by Millenium.

In October 2002, Nelson released The Grey Zone, which he wrote and directed based on his award winning play. It is the dramatic story of the Sonderkommandos, a special squad of Jews who process corpses in the crematoria at Birkenau. Harvey Keitel, Steve Buscemi, and Mira Sorvino star in the film, which premiered at the 2001 Toronto Film Festival. The National Board of Review honored the film with a “Special recognition of films that reflect the freedom of expression” award in 2002.

In 2001, Nelson directed O, a contemporary adaptation of Shakespeare’s Othello, which starred Martin Sheen, Julia Stiles, and Josh Hartnett, and won an award for Best Director at the 2001 Seattle Film Festival.

In 1997, Tim Blake Nelson made his directorial debut with the film, Eye of God, which he also wrote. The film appeared at the 1997 Sundance Film Festival and was released theatrically the same year. It won the top award at the 1997 Seattle Film Festival, as well as the Tokyo Bronze Prize at the Tokyo Film Festival.

Nelson has acted in over 50 feature films including most recently the upcoming Fantastic Four for Fox. The film also stars Kate Mara, Miles Teller, Jamie Bell and Michael B. Jordan. Other film credits include James Franco’s adaptations of The Sound and the Fury, As I Lay Dying, and Child of God, The Homesman, starring Hilary Swank and Tommy Lee Jones, Kill The Messenger with Jeremy Renner, Steven Speilberg’s Lincoln with Daniel Day Lewis, Detachment, starring Adrien Brody and Christina Hendricks, Everybody Loves Whales, starring Drew Barrymore and John Krasinski, David Frankel’s The Big Year with Owen Wilson and Steve Martin, Flypaper with Ashley Judd and Patrick Dempsey, Sin Bin, Yelling To The Sky, American Violet, The Incredible Hulk with Edward Norton and Liv Tyler, The Astronaut Farmer, Fido, Warm Springs, Meet the Fockers, Syriana, Holes, The Good Girl, Wonderland, Minority Report, O Brother Where Art Thou?. He has also acted extensively in New York theatre, appearing in The Beard of Avon, Mad Forest, Oedipus, Troilus and Cressida, Richard III, and Twelfth Night.

His playwriting credits include The Grey Zone, which won him Newsday's Oppenheimer Prize as well as Encore Magazine's “Taking Off” Award, Eye of God and Anadarko.